PittsburghV1, Main, Exploration, bibRecord, 000899

Value of commonly measured laboratory tests as biomarkers of disease activity and predictors of relapse in eosinophilic granulomatosis with polyangiitis

Identifieur interne : 000899 ( Main/Exploration ); précédent : 000898; suivant : 000900

Value of commonly measured laboratory tests as biomarkers of disease activity and predictors of relapse in eosinophilic granulomatosis with polyangiitis

Auteurs : Peter C. Grayson [États-Unis] ; Paul A. Monach [États-Unis] ; Christian Pagnoux [Canada] ; David Cuthbertson [États-Unis] ; Simon Carette [Canada] ; Gary S. Hoffman [États-Unis] ; Nader A. Khalidi [Canada] ; Curry L. Koening [États-Unis] ; Carol A. Langford [États-Unis] ; Kathleen Maksimowicz-Mckinnon [États-Unis] ; Philip Seo [États-Unis] ; Ulrich Specks ; Steven R. Ytterberg [États-Unis] ; Peter A. Merkel [États-Unis]

Source :

Rheumatology (Oxford, England) [ 1462-0324 ] ; 2014.

RBID : PMC:4502335

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Analyse de régression, Femelle, Granulocytes éosinophiles (anatomopathologie), Granulomatose avec polyangéite (diagnostic), Granulomatose avec polyangéite (sang), Humains, Immunoglobuline E (sang), Indice de gravité médicale, Marqueurs biologiques (sang), Mâle, Numération cellulaire, Protéine C-réactive (métabolisme), Récidive, Sujet âgé, Sujet âgé de 80 ans ou plus, Sédimentation du sang, Tests diagnostiques courants (), Valeur prédictive des tests, Éosinophilie (diagnostic), Éosinophilie (sang), Études de cohortes, Études longitudinales.
MESH :
- anatomopathologie : Granulocytes éosinophiles.
- diagnostic : Granulomatose avec polyangéite, Éosinophilie.
- métabolisme : Protéine C-réactive.
- sang : Granulomatose avec polyangéite, Immunoglobuline E, Marqueurs biologiques, Éosinophilie.
- Adulte, Adulte d'âge moyen, Analyse de régression, Femelle, Humains, Indice de gravité médicale, Mâle, Numération cellulaire, Récidive, Sujet âgé, Sujet âgé de 80 ans ou plus, Sédimentation du sang, Tests diagnostiques courants, Valeur prédictive des tests, Études de cohortes, Études longitudinales.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Biomarkers (blood), Blood Sedimentation, C-Reactive Protein (metabolism), Cell Count, Cohort Studies, Diagnostic Tests, Routine (methods), Eosinophilia (blood), Eosinophilia (diagnosis), Eosinophils (pathology), Female, Granulomatosis with Polyangiitis (blood), Granulomatosis with Polyangiitis (diagnosis), Humans, Immunoglobulin E (blood), Longitudinal Studies, Male, Middle Aged, Predictive Value of Tests, Recurrence, Regression Analysis, Severity of Illness Index.
MESH :
- chemical , blood : Biomarkers, Immunoglobulin E.
- chemical , metabolism : C-Reactive Protein.
- blood : Eosinophilia, Granulomatosis with Polyangiitis.
- diagnosis : Eosinophilia, Granulomatosis with Polyangiitis.
- methods : Diagnostic Tests, Routine.
- pathology : Eosinophils.
- Adult, Aged, Aged, 80 and over, Blood Sedimentation, Cell Count, Cohort Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Predictive Value of Tests, Recurrence, Regression Analysis, Severity of Illness Index.

Abstract

Objective. The aim of this study was to assess the clinical value of absolute eosinophil count, serum IgE, ESR and CRP as longitudinal biomarkers of disease activity and predictors of relapse in eosinophilic granulomatosis with polyangiitis (Churg-Strauss, EGPA).

Methods. Patients were selected from an observational EGPA cohort. Absolute eosinophil count, IgE, ESR and CRP were measured quarterly. Disease activity was defined by validated assessment tools. The association of tests with disease activity was assessed via regression models, adjusting for repeated measures and treatment status. Survival analysis was used to determine if laboratory tests were predictive of the 3 month future flare risk.

Results. Seventy-four per cent of 892 study visits in 141 patients occurred while patients were on treatment, mostly during remission or mild disease activity, defined as a BVAS for Wegener’s granulomatosis (BVAS/WG) of 1 or 2. Correlations between absolute eosinophil count, IgE, ESR and CRP were mostly low or non-significant (r = −0.08 to 0.44). There were few weak associations with disease activity [absolute eosinophil count: OR) 1.01/100 U (95% CI 1.01, 1.02); ESR: OR 1.15/10 mg/l increase (95% CI 1.04, 1.27)]. When BVAS/WG ≥1 defined active disease, the absolute eosinophil count [hazard ratio (HR) 1.01/100 U (95% CI 1.01, 1.02)] was weakly predictive of flare. When BVAS/WG ≥3 defined active disease, ESR was weakly predictive of flare [HR 1.52/10 mm/h increase (95% CI 1.17, 1.67)].

Conclusion. The absolute eosinophil count, IgE, ESR and CRP have limitations as longitudinal biomarkers of disease activity or predictors of flare in EGPA. These findings suggest that novel biomarkers of disease activity for EGPA are needed.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502335

DOI: 10.1093/rheumatology/keu427
PubMed: 25406357
PubMed Central: 4502335

Affiliations:

Canada, États-Unis
Floride, Maryland, Massachusetts, Minnesota, Ohio, Ontario, Pennsylvanie, Utah
Hamilton (Ontario)
Université McMaster

Le document en format XML

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<author><name sortKey="Koening, Curry L" sort="Koening, Curry L" uniqKey="Koening C" first="Curry L." last="Koening">Curry L. Koening</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Biomarkers (blood)</term>
<term>Blood Sedimentation</term>
<term>C-Reactive Protein (metabolism)</term>
<term>Cell Count</term>
<term>Cohort Studies</term>
<term>Diagnostic Tests, Routine (methods)</term>
<term>Eosinophilia (blood)</term>
<term>Eosinophilia (diagnosis)</term>
<term>Eosinophils (pathology)</term>
<term>Female</term>
<term>Granulomatosis with Polyangiitis (blood)</term>
<term>Granulomatosis with Polyangiitis (diagnosis)</term>
<term>Humans</term>
<term>Immunoglobulin E (blood)</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Predictive Value of Tests</term>
<term>Recurrence</term>
<term>Regression Analysis</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de régression</term>
<term>Femelle</term>
<term>Granulocytes éosinophiles (anatomopathologie)</term>
<term>Granulomatose avec polyangéite (diagnostic)</term>
<term>Granulomatose avec polyangéite (sang)</term>
<term>Humains</term>
<term>Immunoglobuline E (sang)</term>
<term>Indice de gravité médicale</term>
<term>Marqueurs biologiques (sang)</term>
<term>Mâle</term>
<term>Numération cellulaire</term>
<term>Protéine C-réactive (métabolisme)</term>
<term>Récidive</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Sédimentation du sang</term>
<term>Tests diagnostiques courants ()</term>
<term>Valeur prédictive des tests</term>
<term>Éosinophilie (diagnostic)</term>
<term>Éosinophilie (sang)</term>
<term>Études de cohortes</term>
<term>Études longitudinales</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term>
<term>Immunoglobulin E</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>C-Reactive Protein</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Granulocytes éosinophiles</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Eosinophilia</term>
<term>Granulomatosis with Polyangiitis</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Eosinophilia</term>
<term>Granulomatosis with Polyangiitis</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Granulomatose avec polyangéite</term>
<term>Éosinophilie</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diagnostic Tests, Routine</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéine C-réactive</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Eosinophils</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Granulomatose avec polyangéite</term>
<term>Immunoglobuline E</term>
<term>Marqueurs biologiques</term>
<term>Éosinophilie</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Blood Sedimentation</term>
<term>Cell Count</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Predictive Value of Tests</term>
<term>Recurrence</term>
<term>Regression Analysis</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de régression</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de gravité médicale</term>
<term>Mâle</term>
<term>Numération cellulaire</term>
<term>Récidive</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Sédimentation du sang</term>
<term>Tests diagnostiques courants</term>
<term>Valeur prédictive des tests</term>
<term>Études de cohortes</term>
<term>Études longitudinales</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><bold>Objective.</bold>
 The aim of this study was to assess the clinical value of absolute eosinophil count, serum IgE, ESR and CRP as longitudinal biomarkers of disease activity and predictors of relapse in eosinophilic granulomatosis with polyangiitis (Churg-Strauss, EGPA).</p>
<p><bold>Methods.</bold>
 Patients were selected from an observational EGPA cohort. Absolute eosinophil count, IgE, ESR and CRP were measured quarterly. Disease activity was defined by validated assessment tools. The association of tests with disease activity was assessed via regression models, adjusting for repeated measures and treatment status. Survival analysis was used to determine if laboratory tests were predictive of the 3 month future flare risk.</p>
<p><bold>Results.</bold>
 Seventy-four per cent of 892 study visits in 141 patients occurred while patients were on treatment, mostly during remission or mild disease activity, defined as a BVAS for Wegener’s granulomatosis (BVAS/WG) of 1 or 2. Correlations between absolute eosinophil count, IgE, ESR and CRP were mostly low or non-significant (<italic>r</italic>
 = −0.08 to 0.44). There were few weak associations with disease activity [absolute eosinophil count: OR) 1.01/100 U (95% CI 1.01, 1.02); ESR: OR 1.15/10 mg/l increase (95% CI 1.04, 1.27)]. When BVAS/WG ≥1 defined active disease, the absolute eosinophil count [hazard ratio (HR) 1.01/100 U (95% CI 1.01, 1.02)] was weakly predictive of flare. When BVAS/WG ≥3 defined active disease, ESR was weakly predictive of flare [HR 1.52/10 mm/h increase (95% CI 1.17, 1.67)].</p>
<p><bold>Conclusion.</bold>
 The absolute eosinophil count, IgE, ESR and CRP have limitations as longitudinal biomarkers of disease activity or predictors of flare in EGPA. These findings suggest that novel biomarkers of disease activity for EGPA are needed.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Floride</li>
<li>Maryland</li>
<li>Massachusetts</li>
<li>Minnesota</li>
<li>Ohio</li>
<li>Ontario</li>
<li>Pennsylvanie</li>
<li>Utah</li>
</region>
<settlement><li>Hamilton (Ontario)</li>
</settlement>
<orgName><li>Université McMaster</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Specks, Ulrich" sort="Specks, Ulrich" uniqKey="Specks U" first="Ulrich" last="Specks">Ulrich Specks</name>
</noCountry>
<country name="États-Unis"><region name="Maryland"><name sortKey="Grayson, Peter C" sort="Grayson, Peter C" uniqKey="Grayson P" first="Peter C." last="Grayson">Peter C. Grayson</name>
</region>
<name sortKey="Cuthbertson, David" sort="Cuthbertson, David" uniqKey="Cuthbertson D" first="David" last="Cuthbertson">David Cuthbertson</name>
<name sortKey="Hoffman, Gary S" sort="Hoffman, Gary S" uniqKey="Hoffman G" first="Gary S." last="Hoffman">Gary S. Hoffman</name>
<name sortKey="Koening, Curry L" sort="Koening, Curry L" uniqKey="Koening C" first="Curry L." last="Koening">Curry L. Koening</name>
<name sortKey="Langford, Carol A" sort="Langford, Carol A" uniqKey="Langford C" first="Carol A." last="Langford">Carol A. Langford</name>
<name sortKey="Maksimowicz Mckinnon, Kathleen" sort="Maksimowicz Mckinnon, Kathleen" uniqKey="Maksimowicz Mckinnon K" first="Kathleen" last="Maksimowicz-Mckinnon">Kathleen Maksimowicz-Mckinnon</name>
<name sortKey="Merkel, Peter A" sort="Merkel, Peter A" uniqKey="Merkel P" first="Peter A." last="Merkel">Peter A. Merkel</name>
<name sortKey="Monach, Paul A" sort="Monach, Paul A" uniqKey="Monach P" first="Paul A." last="Monach">Paul A. Monach</name>
<name sortKey="Seo, Philip" sort="Seo, Philip" uniqKey="Seo P" first="Philip" last="Seo">Philip Seo</name>
<name sortKey="Ytterberg, Steven R" sort="Ytterberg, Steven R" uniqKey="Ytterberg S" first="Steven R." last="Ytterberg">Steven R. Ytterberg</name>
</country>
<country name="Canada"><noRegion><name sortKey="Pagnoux, Christian" sort="Pagnoux, Christian" uniqKey="Pagnoux C" first="Christian" last="Pagnoux">Christian Pagnoux</name>
</noRegion>
<name sortKey="Carette, Simon" sort="Carette, Simon" uniqKey="Carette S" first="Simon" last="Carette">Simon Carette</name>
<name sortKey="Khalidi, Nader A" sort="Khalidi, Nader A" uniqKey="Khalidi N" first="Nader A." last="Khalidi">Nader A. Khalidi</name>
</country>
</tree>
</affiliations>
</record>

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Value of commonly measured laboratory tests as biomarkers of disease activity and predictors of relapse in eosinophilic granulomatosis with polyangiitis

Value of commonly measured laboratory tests as biomarkers of disease activity and predictors of relapse in eosinophilic granulomatosis with polyangiitis

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